On New Applications and Sensitivity Enhancement of Cantilever-based Sensing Systems

Cantilever-based Sensing Systems (CSS) have become a focal area for research with the rise of micro- and nanotechnology. History has led us to use cantilever beams as one of the foremost sensing devices for small scale applications, beginning with the atomic force microscopy, and then being expanded into numerous sensor devices. The CSS include such applications as accelerometers, thermal and chemical sensors which are expanding into the applications of mass sensing and material characterization. Soon, this technology may be used in \u27lab on chip\u27 biosensing applications. This study covers the experimentation into new CSS applications and sensitivity enhancement. In order to do this, an overview of CSS is presented. The history of cantilever is covered from its humble beginnings to the recent explosion of interest. Next, working principles, operational modes and microfabrication of the CSS are briefly overviewed. Experimentation into novel CSS applications for material characterization of a thermally sensitive polymer is discussed first. To accomplish this, an array of cantilevers is used to isolate effect of the polymer. The results show that static mode CSS using optical transduction can be effectively used to sense polymers lower critical solution temperature via measuring the beam deflection caused by surface stress due to the polymer instead of repeated traditional surface hydrophobicity tests. In the next part of the thesis, a new CSS design is fabricated and used for mass detection. This new design utilizes stress measurements of an integrated strain gauge with reference cantilever. The new design allows for the measurement of the frequency shift while compensating for environmental effects. The CSS design is characterized and tested utilizing the addition of Au nanoparticles as functional added mass. The final section of this study focuses on an exciting new CSS sensitivity enhancement technique. This new technique utilizes a delayed feedback to create stable limit cycles. The amplitude of these limit cycles is shown to be highly sensitive to changes in tip mass added or attached to the cantilever. The theory is presented and verified utilizing macroscale experimentation. Both theoretical and experimental results demonstrate a two-orders-of magnitude sensitivity enhancement over traditional frequency shift methods

Koinonia

In This IssueThe Fabric of Our Faithfulness: Part 1, David S. Guthrie What is the Sophomore Slump-and Why Should We Care?: Excerpted from Visible Solutions for Invisible Students: Helping Sophomores Succeed, by Laurie A. Schreiner & Jerry Pattengale Around CampusServant Leadership, Tess Bradley The 7 Be\u27s of Student Leader Supervision, Jesse Brown Spotlight on SpeakersJohn 7:53-8:11: The Politically Correct Version, Calvin Miller Regular FeaturesPresident\u27s Corner Editor\u27s Disk ACSD Business: Placement Services 2001, Conference Thoughts: Something Old...Something New..., Submissions Soughthttps://pillars.taylor.edu/acsd_koinonia/1031/thumbnail.jp

SMAP Soil Moisture Change as an Indicator of Drought Conditions

Soil moisture is considered a key variable in drought analysis. The soil moisture dynamics given by the change in soil moisture between two time periods can provide information on the intensification or improvement of drought conditions. The aim of this work is to analyze how the soil moisture dynamics respond to changes in drought conditions over multiple time intervals. The change in soil moisture estimated from the Soil Moisture Active Passive (SMAP) satellite observations was compared with the United States Drought Monitor (USDM) and the Standardized Precipitation Index (SPI) over the contiguous United States (CONUS). The results indicated that the soil moisture change over 13-week and 26-week intervals is able to capture the changes in drought intensity levels in the USDM, and the change over a four-week interval correlated well with the one-month SPI values. This suggested that a short-term negative soil moisture change may indicate a lack of precipitation, whereas a persistent long-term negative soil moisture change may indicate severe drought conditions. The results further indicate that the inclusion of soil moisture change will add more value to the existing drought-monitoring products

Science and the Liberal Arts at Ursinus College

Science trend: Moving beyond industrialism • Founders\u27 Day address: Small colleges nurture young scientists well • Physics mentor changed a life • Complex world a challenge for scientists • In government, chemist finds his niche • Ursinus helps non standard student bloom • Ursinus let him explore inner space • Finding the problem is scientist\u27s hardest task • Most wanted: Insatiable curiosity • Real research: Practical or esoteric? • Flexibility is a matter of degree • Liberal arts education prepares minds • The way to encourage young scientistshttps://digitalcommons.ursinus.edu/founders_programs/1053/thumbnail.jp

Allelic Variation on Murine Chromosome 11 Modifies Host Inflammatory Responses and Resistance to Bacillus anthracis

Anthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced by pathogen-encoded virulence factors such as lethal toxin (LT), as well as by genetic variation within the host. To identify host genes controlling susceptibility to anthrax, a library of congenic mice consisting of strains with homozygous chromosomal segments from the LT-responsive CAST/Ei strain introgressed on a LT-resistant C57BL/6 (B6) background was screened for response to LT. Three congenic strains containing CAST/Ei regions of chromosome 11 were identified that displayed a rapid inflammatory response to LT similar to, but more severe than that driven by a LT-responsive allele of the inflammasome constituent NRLP1B. Importantly, increased response to LT in congenic mice correlated with greater resistance to infection by the Sterne strain of B. anthracis. The genomic region controlling the inflammatory response to LT was mapped to 66.36–74.67 Mb on chromosome 11, a region that encodes the LT-responsive CAST/Ei allele of Nlrp1b. However, known downstream effects of NLRP1B activation, including macrophage pyroptosis, cytokine release, and leukocyte infiltration could not fully explain the response to LT or the resistance to B. anthracis Sterne in congenic mice. Further, the exacerbated response in congenic mice is inherited in a recessive manner while the Nlrp1b-mediated response to LT is dominant. Finally, congenic mice displayed increased responsiveness in a model of sepsis compared with B6 mice. In total, these data suggest that allelic variation of one or more chromosome 11 genes in addition to Nlrp1b controls the severity of host response to multiple inflammatory stimuli and contributes to resistance to B. anthracis Sterne. Expression quantitative trait locus analysis revealed 25 genes within this region as high priority candidates for contributing to the host response to LT

Visible and near-infrared multispectral analysis of geochemically measured rock fragments at the Opportunity landing site in Meridiani Planum

We have used visible and near‐infrared Panoramic Camera (Pancam) spectral data acquired by the Opportunity rover to analyze 15 rock fragments at the Meridiani Planum landing site. These spectral results were then compared to geochemistry measurements made by the in situ instruments Mössbauer (MB) and Alpha Particle X‐ray Spectrometer (APXS) to determine the feasibility of mineralogic characterization from Pancam data. Our results suggest that dust and alteration rinds coat many rock fragments, which limits our ability to adequately measure the mineralogy of some rocks from Pancam spectra relative to the different field of view and penetration depths of MB and APXS. Viewing and lighting geometry, along with sampling size, also complicate the spectral characterization of the rocks. Rock fragments with the same geochemistry of sulfate‐rich outcrops have similar spectra, although the sulfate‐rich composition cannot be ascertained based upon Pancam spectra alone. FeNi meteorites have spectral characteristics, particularly ferric oxide coatings, that generally differentiate them from other rocks at the landing site. Stony meteorites and impact fragments with unknown compositions have a diverse range of spectral properties and are not well constrained nor diagnostic in Pancam data. Bounce Rock, with its unique basalt composition, is easily differentiated in the Pancam data from all other rock types at Meridiani Planum. Our Pancam analyses of small pebbles adjacent to these 15 rock fragments suggests that other rock types may exist at the landing site but have not yet been geochemically measured

Seasonal melting and the formation of sedimentary rocks on Mars, with predictions for the Gale Crater mound

A model for the formation and distribution of sedimentary rocks on Mars is proposed. The rate-limiting step is supply of liquid water from seasonal melting of snow or ice. The model is run for a O(10^2) mbar pure CO2 atmosphere, dusty snow, and solar luminosity reduced by 23%. For these conditions snow only melts near the equator, and only when obliquity >40 degrees, eccentricity >0.12, and perihelion occurs near equinox. These requirements for melting are satisfied by 0.01-20% of the probability distribution of Mars' past spin-orbit parameters. Total melt production is sufficient to account for aqueous alteration of the sedimentary rocks. The pattern of seasonal snowmelt is integrated over all spin-orbit parameters and compared to the observed distribution of sedimentary rocks. The global distribution of snowmelt has maxima in Valles Marineris, Meridiani Planum and Gale Crater. These correspond to maxima in the sedimentary-rock distribution. Higher pressures and especially higher temperatures lead to melting over a broader range of spin-orbit parameters. The pattern of sedimentary rocks on Mars is most consistent with a Mars paleoclimate that only rarely produced enough meltwater to precipitate aqueous cements and indurate sediment. The results suggest intermittency of snowmelt and long globally-dry intervals, unfavorable for past life on Mars. This model makes testable predictions for the Mars Science Laboratory rover at Gale Crater. Gale Crater is predicted to be a hemispheric maximum for snowmelt on Mars.Comment: Submitted to Icarus. Minor changes from submitted versio

Multiwavelength Constraints on the Origin of a Nearby Repeating Fast Radio Burst Source in a Globular Cluster

Since fast radio bursts (FRBs) were discovered, their precise origins have remained a mystery. Multiwavelength observations of nearby FRB sources provide one of the best ways to make rapid progress in our understanding of the enigmatic FRB phenomenon. We present results from a sensitive, broadband multiwavelength X-ray and radio observational campaign of FRB 20200120E, the closest known extragalactic repeating FRB source. At a distance of 3.63 Mpc, FRB 20200120E resides in an exceptional location, within a ~10 Gyr-old globular cluster in the M81 galactic system. We place deep limits on both the persistent X-ray luminosity and prompt X-ray emission at the time of radio bursts from FRB 20200120E, which we use to constrain possible progenitors for the source. We compare our results to various classes of X-ray sources and transients. In particular, we find that FRB 20200120E is unlikely to be associated with: ultraluminous X-ray bursts (ULXBs), similar to those observed from objects of unknown origin in other extragalactic globular clusters; giant flares, like those observed from Galactic and extragalactic magnetars; or most intermediate flares and very bright short X-ray bursts, similar to those seen from magnetars in the Milky Way. We show that FRB 20200120E is also unlikely to be powered by a persistent or transient ultraluminous X-ray (ULX) source or a young, extragalactic pulsar embedded in a Crab-like nebula. We also provide new constraints on the compatibility of FRB 20200120E with accretion-based FRB models involving X-ray binaries and models that require a synchrotron maser process from relativistic shocks to generate FRB emission. These results highlight the power that multiwavelength observations of nearby FRBs can provide for discriminating between potential FRB progenitor models.Comment: 58 pages, 10 figures, 7 tables, submitte